Hydroxy-substituted amino and ammonium derivatives and their medical use
AssigneeGri Bio, Inc.
InventorsGeorg Schlechtingen, Hans-Joachim Knolker, Tim Friedrichson, Gary Jennings, Tobias Braxmeier
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Abstract
The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula 1 or 2, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
Claims13
1-32. (canceled)
A method of inhibiting mast cell degranulation, Akt kinase, delayed-type hypersensitivity, allergic contact dermatitis inflammatory response, or collagen type II-induced arthritis, the method comprising administering an effective amount to a subject in need of such a treatment, a compound of the following formula 1
- wherein:
- R1 is a C10-20 hydrocarbon group;
- R2 is a C1-4 alkyl group, and R3 is —H, a C1-4 alkyl group or R3 is absent;
- R4 is —H or a C1-4 alkyl group;
- R5 is a C2-g alkyl group, wherein one or more hydrogen atoms of said C2-8 alkyl group are replaced by —OH, or R5 is a C5-7 cycloalkyl group, wherein one ring carbon atom of said C5-7 cycloalkyl group is optionally replaced by an oxygen atom and wherein one or more hydrogen atoms of said C5-7 cycloalkyl group are independently replaced by —OH or —CH2OH;
- X is N+ or, if R3 is absent, X is N;
- and
- p is 1, 2 or 3;
- or a pharmaceutically acceptable salt, or solvate thereof.
Dependencies are inferred from the claim text.