Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

A system for detecting glucose in a biological sample, comprising:

• at least one light source configured to generate one or more light beams to strike a target area of a sample;
• at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected;
• a light absorbance change determining algorithm implemented processor programmed to calculate a change in a light absorption caused by blood in the biological sample and configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with either a normalization factor or a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area;
• an analog-to-digital converter having a digitized voltage output, wherein the light absorbance change determining algorithm implemented processor is configured to calculate the normalization factor Qi(C,T) based on an analog-to-digital converter voltage output Δ(ADC)i of an ith analog-to-digital converter, where σ is a standard deviation according to the equation:
• Qi(C,T)=σ[log Δ(ADC)i]/Σi=1Nσ[log Δ(ADC)i] or a ratio factor Yij(C,T) based on the analog-to-digital converter voltage output Δ(ADC)i of the ith analog-to-digital converter and an analog-to-digital converter voltage output Δ(ADC)i of a jth analog-to-digital converter, where a is a standard deviation according to the equation:
• Yij(C,T)=σ[log Δ(ADC)i]/σ[log Δ(ADC)j], wherein T is a temperature of the biological sample and C is a concentration of blood glucose in the biological sample.

A system for detecting glucose in a biological sample comprising:

• at least one light source configured to generate one or more light beams to strike a target area of a sample;
• at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected;
• a light absorbance change determining algorithm implemented processor programmed to calculate a change in a light absorption caused by blood in the biological sample and configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with either a normalization factor or a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area;
• and
• an analog-to-digital convertor having a digitized voltage output.

A system for detecting glucose in a biological sample, wherein the system comprises a processor configured to determine a change in a light absorption caused by blood in the biological sample, determine an attenuance attributable to blood in a sample present in a target area with either a normalization factor or a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of a photocurrent signal generating light detector by calculating a standard deviation of a logarithm of a time dependent output current, and determine a blood glucose level associated with the sample present in the target area based on the determined attenuance, wherein the device is configured to calculate the normalization factor Qi(C,T) based on the preamplifier output voltage Vi(t) of an ith preamplifier as a function of time, where σ is standard deviation according to the equation:

• Q
• i
• ⁡
• (
• C
• ,
• T
• )
• =
• σ
• ⁡
• [
• log
• ⁢
• V
• i
• ⁡
• (
• t
• )
• ]
• Σ
• i
• =
• 1
• N
• ⁢
• σ
• ⁡
• [
• log
• ⁢
• V
• i
• ⁡
• (
• t
• )
• ]
• or a ratio factor Yij(C,T) based on the preamplifier output voltage Vi(t) of an ith preamplifier and the preamplifier voltage Vj(t) of a jth preamplifier as a function of time, where σ is standard deviation according to the equation:
• Y
• i
• ⁢
• j
• ⁡
• (
• C
• ,
• T
• )
• =
• σ
• ⁡
• [
• log
• ⁢
• V
• i
• ⁡
• (
• t
• )
• ]
• σ
• ⁡
• [
• log
• ⁢
• V
• j
• ⁡
• (
• t
• )
• ]
• ,
• wherein T is a temperature of the biological sample and C is a concentration of blood glucose in the biological sample.