Induced immunological response to cancerous cells using vectors containing viral genes
OwnerWalter W. Allerinventor
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Abstract
A method for treating cancer in mammals using an expression vector to transfect cancer cells in vivo and in situ. The vector includes one or more immunogenic exogenous polypeptides that are expressed by the cancer cells upon transfection. The body's immune response is triggered and directed to attack the transfected cancer cells. Once the immune response to the exogenous peptide on the cancer cells is initiated, an immune response to the other cancer associated or cancer specific antigens on or in the cancer cells takes over and eliminates all cancer cells, transfected or not.
Claims4
A method of treating cancer in a mammal comprising transfecting tumors in vivo and in situ with a vector (plasmid or viral) that expresses an exogenous immunogenic polypeptide of viral, fungal, bacterial, non-human mammal or non-animal plant origin.
A method of treating cancer in a mammal comprising transfecting tumor cells in vivo using a vector including and expressing an exogenous immunogenic polypeptide of viral, fungal, non-human mammal or non-animal plant origin that also includes an immunostimulatory moiety such that both the immunogenic polypeptide and the immunostimulatory entity are co-expressed at the same time in the same transfected cells.
Dependencies are inferred from the claim text.