Mammal-specific Growth-defective Arbovirus
AssigneeTenGen Biomedical Company
InventorsXiaowu Pang, Xinbin Gu
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Abstract
Arbovirus carries an altered furin cleavage site that results in enhanced cleavage of a precursor polyprotein, such as, prE2 or prM. Dengue virus particles can have an amino acid alteration within amino acids 80-130 of prM. Zika virus particles can have alterations at amino residues at and/or about the furin cleavage site. The virus can be produced in insect cells. The virus does not form progeny virus in mammal cells.
Claims20
An arbovirus particle comprising a growth-restricted Arbovirus comprising a dysfunctional furin tetrapeptide cleavage site in a precursor polyprotein, and optionally, an alteration in a first stretch of amino acids upstream from said site and/or an alteration in a second stretch of amino acids downstream from said site.
Dependencies are inferred from the claim text.