Crystal forms of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, processes of making such forms, and their pharmaceutical compositions

A method of selecting a solid form of A2-73 or ANAVEX19-144, the method comprising:

• a. making a plurality of solutions of A2-73 or ANAVEX19-144, each solution having a different solvent;
• b. introducing the plurality of solutions to a super critical fluid (SCF);
• c. allowing crystallization of A2-73 or ANAVEX19-144 in a SCF environment to form a plurality of crystals;
• d. isolating the plurality of crystals;
• and
• e. measuring for each of the plurality of crystals at least one property selected from PXRD, FTIR, DSC, SEM, stability, flow characteristics, and any combination thereof;
• and
• f. selecting a crystal from the plurality of crystals, wherein the crystal meets a predetermined measurement for at least one property in (e).