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AssigneesKorea Advanced Institute of Science and Technology, Hanwha Solutions Corporation
InventorsSang Yup LEE, Jae Sung CHO, Je Woong KIM, Cindy Pricilia Surya PRABOWO, Taehee HAN, Yoo Sung KO
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The present invention relates to recombinant Corynebacterium having 1,3-PDO productivity and reduced 3-HP productivity, and a method for producing 1,3-PDO by using same. When a Corynebacterium glutamicum variant according to the present invention is used, the productivity of 3-HP, which is a by-product, is inhibited by using low-cost glycerol as a carbon source, and thus 1,3-PDO can be produced with high efficiency.
A mutant microorganism having deleted or attenuated 3-HP production ability and producing 1,3-PDO from glycerol, in which (i) a gene encoding a glycerol facilitator, (ii) a gene encoding glycerol kinase and a gene encoding glycerol dehydrogenase, (iii) a gene encoding glycerol dehydratase, (iv) a gene encoding glycerol reactivase and (v) a gene encoding 1,3-PDO oxidoreductase are introduced into Corynebacterium glutamicum, and a gene encoding aldehyde dehydrogenase is deleted or attenuated from the Corynebacterium glutamicum.
Dependencies are inferred from the claim text.