Diagnosis of melanoma and solar lentigo by nucleic acid analysis
AssigneeDermtech, Inc.
InventorSherman H. Chang
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Abstract
The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample
Claims20
A method for non-invasive collection and analysis of a skin sample, the method comprising:
- receiving an adhesive skin sample collection kit comprising at least one adhesive tape, wherein the adhesive tape comprises:
- an adhesive matrix on a first surface of a collection area;
- and
- a skin sample adhered to the adhesive matrix, wherein the adhesive tape comprises a demarcation indicative of a region to be processed;
- and
- quantifying expression levels of one or more target genes in the skin sample.
A system for non-invasive collection and analysis of a skin sample, the system comprising:
- an adhesive skin sample collection kit comprising at least one adhesive tape, wherein the at least one adhesive tape comprises a collection area comprising an adhesive matrix on a first surface of the collection area, wherein the collection area comprises a demarcation indicative of a region to be processed, and wherein the adhesive matrix is configured to adhere to an effective amount of a skin sample for quantifying expression levels of one or more target genes in the skin sample.
Dependencies are inferred from the claim text.