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US 2021/0198741 A1Published application
Identification of spatial biomarkers of heart disorders and methods of using the same
OwnerStephen R. Williamsinventor
Life of this patent
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Abstract
Provided herein are methods of detecting biomarkers and/or candidate biomarkers for heart disorders and uses of the same.
Claims27
(canceled)
A method of determining abundance of two or more analytes in a subject having a heart disease or disorder, comprising:
- determining the abundance of the two or more analytes selected from the group consisting of ribosomal protein L36a (RPL36A), ferritin light chain (FTL), ribosomal protein L37 (RPL37), ribosomal protein S17 (RPS17), ribosomal protein S29 (RPS29), pancreatic progenitor cell differentiation and proliferation factor (PPDPF), Y-box binding protein 3 (YBX3), ribosomal protein L34 (RPL34), ribosomal protein L38 (RPL38), ribosomal protein S21 (RPS21), ribosomal protein S10 (RPS10), ribosomal protein S25 (RPS25), ribosomal protein L26 (RPL26), ribosomal protein L37a (RPL37A), ribosomal protein S15a (RPS15A), ribosomal protein S27 (RPS27), ribosomal protein L23 (RPL23), ATP synthase F1 subunit epsilon (ATP5F1E), ribosomal protein S8 (RPS8), ribosomal protein L31 (RPL31), ribosomal protein S28 (RPS28), fatty acid binding protein 4 (FABP4), ribosomal protein L22 (RPL22), ribosomal protein L39 (RPL39), complement C1q B chain (C1QB), translation machinery associated 7 homolog (TMA7), ribosomal protein L23a (RPL23A), NADH:ubiquinone oxidoreductase subunit A1 (NDUFA1), cytochrome c oxidase subunit 7C (COX7C), ferritin heavy chain 1 (FTH1), and byproducts, precursors, and degradation products thereof, in a biological sample obtained from the subject.
(canceled)
A method of treating heart disease or disorder in a subject, wherein the method comprises:
- (a) determining an abundance of two or more analytes selected from RPL36A, FTL, RPL37, RPS17, RPS29, PPDPF, YBX3, RPL34, RPL38, RPS21, RPS10, RPS25, RPL26, RPL37A, RPS15A, RPS27, RPL23, ATP5F1E, RPS8, RPL31, RPS28, FABP4, RPL22, RPL39, C1QB, TMA7, RPL23A, NDUFA1, COX7C, FTH1, and byproducts, precursors, and degradation products thereof, in a biological sample from the subject;
- and
- (b) identifying the subject having at least one of:
- (1) an elevated abundance of the two or more analytes RPS21, RPS10, RPS25, RPL26, RPL37A, RPS15A, RPS27, RPL23, ATP5F1E, RPS8, RPL31, RPS28, FABP4, RPL22, RPL39, C1QB, TMA7, RPL23A, NDUFA1, COX7C, FTH1, and byproducts, precursors, and degradation products thereof, of step (a), as compared to the reference expression level(s) of the two or more analytes RPS21, RPS10, RPS25, RPL26, RPL37A, RPS15A, RPS27, RPL23, ATP5F1E, RPS8, RPL31, RPS28, FABP4, RPL22, RPL39, C1QB, TMA7, RPL23A, NDUFA1, COX7C, FTH1 and byproducts, precursors, and degradation products thereof;
- and
- (2) about the same or a decreased abundance of the two or more analytes RPL36A, FTL, RPL37, RPS17, RPS29, PPDPF, YBX3, RPL34, RPL38, and byproducts, precursors, and degradation products thereof, of step (a), as compared to the reference expression level(s) of the two or more analytes RPL36A, FTL, RPL37, RPS17, RPS29, PPDPF, YBX3, RPL34, RPL38, and byproducts, precursors, and degradation products thereof;
- as having a heart disease or disorder;
- and
- (c) administering a treatment for heart disease or disorder to the subject.
6 more elements
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32-39. (canceled)
Dependencies are inferred from the claim text.