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US 2021/0198737 A1Published application
Circulating serum microrna biomarkers and methods for parkinson's disease prognosis
AssigneeSt. John's University
InventorsSimon Geir Moller, Indranil Basak, Ketan Patil, Jan Petter Larsen, Guido Werner Alves
Life of this patent
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Abstract
Biomarkers and methods for identifying, verifying and confirming circulating serum-based microRNAs. The microRNAs (PrognomiRs) can be used to differentiate patient's suffering from rapid progressing Parkinson's disease (PD) from slow progressing PD patients.
Claims40
A method for determining the rate of progression of Parkinson's disease in a human patient, comprising the steps of:
- obtaining a sample from said human patient;
- and
- determining the level of expression of at least one miRNA selected from the group consisting of SEQ ID NOS:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51 and 52 within said sample.
1 more element
A method for determining the rate of progression of Parkinson's disease in a human patient, comprising the steps of:
- obtaining a sample from said human patient;
- and
- determining the level of expression of at least one miRNA selected from the group consisting of SEQ ID NOS:
- 1, 12, 33, 42 and 45 within said sample.
1 more element
Dependencies are inferred from the claim text.