Recombinant lysins
OwnerVincent FISCHETTI, Assaf RAZ +1inventors
InventorsVincent FISCHETTI, Assaf RAZ, Martin ANDERSSON
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Abstract
Provided are methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-negative bacteria, including Klebsiella, Enterobacter, and Pseudomonas, and related conditions. The compositions and methods utilize Klebsiellapneumonia, Enterobacter, and Pseudomonas derived bacteriophage lysins, and variants thereof, including truncations thereof.
Claims22
A pharmaceutical composition for killing Gram-negative bacteria comprising an effective amount of at least one isolated or recombinant lysin polypeptide comprising one amino acid sequence of Table 1, or variants thereof having at least 80% identity to the least one polypeptide of Table 1, and wherein optionally a recombinant lysin polypeptide comprises an additional amino acid sequence that is a purification tag, or an antimicrobial peptide.
16-21. (canceled)
A recombinant DNA molecule comprising a DNA sequence that encodes a lysin polypeptide from Table 1, or a variant thereof having at least 80% identity to the lysin polypeptide of Table 1.
24-27. (canceled)
Dependencies are inferred from the claim text.