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US 2021/0198265 A1Published application
Temozolomide compounds, polymers prepared therefrom, and method of treating a disease
AssigneeUniversity of Massachusetts
InventorsTodd Emrick, Matthew Skinner, Sarah M. Ward, Banishree Saha
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Abstract
A temozolomide compound according to formula (I) is described, wherein R1, L1, and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.
Claims18
A temozolomide compound of structure (I)
- wherein
- X is —O— or —NRa—, wherein Ra is hydrogen or a C1-6 alkyl group;
- L is a divalent C1-12 alkylene group, di(C2-12 alkylene) disulfide group, C2-12 alkylene ester group, C6-20 arylene group, C1-20 alkylene oxide group, or C1-12 alkylene sulfide group;
- n is 0 or 1;
- and
- R1 is a pentafluorophenyl group, a pyridyl disulfide group, a zwitterionic group, a glutathione group, or a thiamine group;
- provided that when R1 is a pentafluorophenyl group, X is —O— and n is 0.
4 more elements
Dependencies are inferred from the claim text.