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US 2021/0198260 A1Published application
Novel phosphor-tetrazine compound and use thereof
AssigneesSpark Biopharma, Inc., Seoul National University R&Db Foundation
InventorsSeung Bum PARK, Young LEE
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Abstract
The present invention relates to a novel phosphor-tetrazine and a use thereof and, more particularly, provides a novel compound having high fluorescence amplification efficiency in various wavelength ranges by using a compound having a novel core skeleton called tert-butyl (3-(7-(6-methyl-1,2,4,5-tetrazin-3 -yl)-3-oxo-9-phenyl-1H-pyrrolo[3,4-b]indolizin-2(3H)-yl)propyl)carbamate.
Claims8
A compound represented by Formula 1 below:
- in which,
- R1 is hydrogen, C1-C6 alkoxy, hydroxy or NR4R5 (wherein, R4 and R5 are each independently hydrogen, a C1-C6 alkyl group or a C3-C8 cycloalkyl group),
- R2 is hydrogen, a C1-C6 alkyl, C6-C20 aryl or C4-C20 heteroaryl group, and
- R3 is hydrogen, hydroxy, an alcohol protected by triisopropylsilyl (TIPS), a C3-C8 heterocyclic or amine group,
- wherein the heterocyclic or amine group may or may not be substituted with C1-C6 alkyl;
- a carboxylC1-C6alkyl or tert-butyloxycarbonyl group (Boc group).
3 more elements
Dependencies are inferred from the claim text.