Heterocyclic derivatives and use thereof

A heterocyclic compound of the following Formula 1, or a pharmaceutically acceptable salt or isomer thereof:

• wherein
• each of X1, X2, X3 and X4 is independently C or N;
• R1 is a saturated or unsaturated 3-12-membered mono- or poly-heterocyclyl containing 1-3 heteroatoms (preferably the heteroatoms selected from N, O and S), wherein R1 is unsubstituted or substituted with 1-3 substituents selected from —C1-C6 alkyl and -amino-C1-C6 alkyl;
• R2, R3, R4 and R5 may be the same or different;
• and each of them is independently selected from —H, —C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 perhaloalkyl, -amino-C1-C6 alkyl, —C3-C8cycloalkyl, -halogen (—F, —Cl, —Br, —I), —CN, —C1-C6 alkoxy, —C1-C6 haloalkoxy, —C1-C6 perhaloalkoxy, —C2-C7 alkenyl, —C2-C8 alkynyl, -amino, -aceto, -amido, -sulfonamide, -sulfonyl, -aminosulfonyl-C1-C6 alkyl, —C1-C6 alkylcarboxyl, -carboxyl (—COOH), —C1-C6 acyl, —OH, -nitro (—NO2), —C6-C10 aryl, -heterocyclyl, and —O—C1-C6 alkyl-heterocyclyl, wherein the heterocyclyl is a saturated or unsaturated 3-6-membered heterocyclyl containing 1-3 heteroatoms (preferably heteroatoms selected from N, O and S);
• provided that when X1 is N, R2 does not exist;
• when X2 is N, R3 does not exist;
• when X3 is N, R4 does not exist;
• and when X4 is N, R5 does not exist;
• and when all of X1, X2, X3 and X4 are C, R3 is not hydrogen or fluorine (F);
• each of Y1 and Y2 is independently C or N;
• A ring is a saturated or unsaturated 5- or 6-membered heterocycle containing at least 2 heteroatoms (preferably the heteroatoms selected from N, O and S);
• and
• each of R6 and R7 is independently oxo (═O) or ═NH, and one of R6 and R7 may not exist;
• wherein each of the alkyl, cycloalkyl, heterocyclyl, alkoxy, alkenyl, alkynyl, acyl and aryl groups may be independently unsubstituted or substituted with one or more substituents (for example, 1-3 substituents) selected from the group consisting of —C1-C4 alkyl, -halogen (—F, —Cl, —Br, —I), —CN, —C1-C4alkoxy, -amino, -amido, -carboxyl (—COOH), —C1-C6 acyl, —OH, -nitro (—NO2), heterocyclyl and phenyl, wherein the heterocyclyl is a saturated or unsaturated 3-6-membered heterocyclyl containing 1-3 heteroatoms (preferably, the heteroatoms selected from N, O and S).