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US 2021/0198253 A1Published application
Crystal form of 1h-imidazo[4,5-b]pyridine-2(3h)-one compound and preparation process therefor
AssigneeShijiazhuang Sagacity New Drug Development Company, Ltd.
InventorsMaoyi LEI, Yu XU, Yunfu LUO
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Abstract
Disclosed are a crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and a preparation process therefor, and use of the crystal form in the manufacture of a medicament for treating a disease associated with PDE4 receptor.
Claims16
A Crystal Form A of Compound 1, wherein
- the Crystal Form A has an X-ray powder diffraction pattern having characteristic diffraction peaks at the following 2θ angles:
- 14.10±0.2°, 19.07±0.2°, 21.79±0.2°.
A process for preparing the Crystal Form A of Compound 1, comprising
- adding Compound 1 into an alcohol solvent, a ketone solvent, an ether solvent, a mixed solvent of alcohol solvent and water, a mixed solvent of ketone solvent and water or a mixed solvent of ether solvent and water;
- heating for dissolution, and then cooling for crystallization to obtain the Crystal Form A.
Dependencies are inferred from the claim text.