US 2021/0196938 A1Published application

Method for manufacturing transdermal absorption sheet

AssigneeFUJIFILM Corporation

InventorKenichiro TAMAKI

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Abstract

Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50). In the step of peeling off, pressing force is applied to a part of the step portion (52) in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet (120) is released from the mold (50), and the transdermal absorption sheet (120) is aspirated with a vacuum suction pad (160) from a side opposite to the mold (50) so that the transdermal absorption sheet (120) is peeled off from the mold (50) in the first direction (A).

Claims7

Dependent claims

A method for manufacturing a transdermal absorption sheet, comprising:

a step of filling needle-like recess portions of a mold, which includes the needle-like recess portions and a step portion that is formed around a region where the needle-like recess portions are formed and is higher than the region, with a drug solution and drying the drug solution so as to form a drug layer;
a step of supplying a polymer layer forming solution to the inside of the step portion;
a step of drying the polymer layer forming solution so as to form a polymer layer and a transdermal absorption sheet;
and
a step of peeling off the transdermal absorption sheet from the mold,
wherein in the step of peeling off, pressing force is applied to a part of the step portion in a second direction opposite to a first direction in which the transdermal absorption sheet is released from the mold, and the transdermal absorption sheet is aspirated by a vacuum suction pad from a side opposite to the mold so that the transdermal absorption sheet is peeled off from the mold in the first direction, and
wherein the pressing force is applied using a pressing jig including a tubular base portion and claw portions connected to the base portion by bringing the claw portions into contact with the step portion.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/202,360Filed 16 Mar 2021
Priority: JP 2018-18024626 Sep 2018
Published: 1 Jul 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification31 codes

A61M 37/0015
Other apparatus for introducing media into the body ; Percutany, i.e. introducing medicines into the body by diffusion through the skin: by using…
B29C 33/3807
Characterised by the material or the manufacturing process: resin-bonded materials, e.g. inorganic particles
B29C 33/405
Plastics, e.g. foam or rubber: elastomers, e.g. rubber
B29C 33/442
With means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles: with mechanical ejector or drive means…

Family

Application17/202,360Continuation
US 11,160,965 B2Related patent
US 2021/0196938 A1This patent

From the US filing history. Foreign family members aren’t listed.

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