Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
AssigneeThe Johns Hopkins University
InventorsLaura Ensign, Justin Hanes, Abhijit Date, Yoo Chun Kim
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Abstract
Hypotonic gelling vehicles are used as solubilizing agents for drugs and as a means to provide sustained drug delivery to a mucosal tissue. Solubilizing drugs at higher concentrations enhances drug penetration into the tissues of the body, while the hypotonic gelling vehicle further improves distribution of the drug over a larger surface area for increased absorption and sustained release for reduced side effects and longer duration of action.
Claims21
A method for treating an eye disease comprising administering to the eye once a week or less frequently a formulation comprising
- a therapeutic, prophylactic, nutraceutical, or diagnostic agent,
- a gel-forming polymer for application to the eye, formulated so that it is at a concentration below the critical gel concentration (CGC) of the polymer under isotonic conditions at a temperature between about 25 to about 37° C., and
- excipients to form a pharmaceutically acceptable hypotonic formulation of the polymer suitable for delivery to the eye of an individual in need thereof.
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Dependencies are inferred from the claim text.