Methods of Treating Metabolic Disease
AssigneePfizer Inc.
InventorsAlexander Hal Drakesmith, João André Traila Arezes, Simon John Draper, Kirsty Anne McHugh, Fredrik Karpe, Nathan Denton, Orla Cunningham, Niall John Foy, Reema Jasuja
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Abstract
The present invention further relates to methods for treating a disease of iron metabolism and disease of fat or carbohydrate metabolism using a BMP agonist or antagonist
Claims27
A BMP agonist for use in treating a disease of iron metabolism, wherein the BMP agonist
- (a) inhibits the interaction between BMP or a BMP polypeptide having BMP activity and ERFE or an ERFE polypeptide having erythroferrone activity and/or inhibits the inhibition of BMP activity by ERFE or an ERFE polypeptide having erythroferrone activity,
- (b) binds to BMP or a BMP polypeptide having BMP activity and prevents its interaction with and/or inhibition by an antagonist,
- (c) binds to an antagonist of BMP or a BMP polypeptide having BMP activity and prevents its interaction with and/or inhibition of BMP,
- (d) binds to BMP or a BMP polypeptide having BMP activity and prevents its interaction with and/or inhibition by ERFE or ERFE polypeptide having erythroferrone activity,
- (e) binds to ERFE or an ERFE polypeptide having erythroferrone activity and prevents or inhibits its interaction with BMP or a BMP polypeptide having BMP activity and/or inhibition of BMP activity,
- (f) binds to BMP or a BMP polypeptide having BMP activity and enhances its interaction with a BMP receptor, or
- (g) binds to a BMP receptor and enhances its interaction with its BMP or BMP polypeptide having BMP activity.
A BMP agonist or antagonist for use in treating a disease of lipid or carbohydrate metabolism.
A pharmaceutical composition comprising the BMP agonist or antagonist for use according to any preceding claim wherein the pharmaceutical composition comprises one or more BMP agonist or antagonist and a pharmaceutically acceptable carrier and/or an excipient.
Dependencies are inferred from the claim text.