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US 2021/0196794 A1Published application
Fgf21 variant, fusion protein and application thereof
AssigneeSunshine Lake Pharma Co., Ltd.
InventorsChao CHEN, Shushan LIN, Yu LI, Xiaofeng CHEN, Wenjia LI, Liang LIU, Zheng FU
Life of this patent
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Abstract
A fibroblast growth factor 21 (FGF21) variant, further to a FGF21 variant fusion protein, a protein multimer, and use thereof can significantly improve the binding ability with the target and can be used to treat metabolic diseases.
Claims21
1-28. (canceled)
An amino acid sequence of a FGF21 variant includes one or more amino acid substitutions compared to the amino acid sequence shown in SEQ ID NO:
- 1, the one or more amino acid substitutions comprising an amino acid substitution at position 167, wherein the amino acid substitution at position 167 is S167H.
Dependencies are inferred from the claim text.