Compositions comprising bacterial strains
Assignee4D Pharma PLC
InventorsIan JEFFERY, Fergus SHANAHAN, Paul O'TOOLE, Alex STEVENSON, Imke MULDER, Helene SAVIGNAC
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Abstract
Provided are compositions comprising a bacterial strain of the genus Blautia, for use in a method of increasing the microbiota diversity and/or stability of the microbiota of a subject.
Claims18
-40. (canceled)
A method of inducing a temporal variation in the microbiota of a subject having a stroke in need thereof, comprising administering to the subject a composition that comprises a therapeutically effective amount of a bacteria strain of the genus Blautia with at least 95% sequence identity to the polynucleotide sequence of SEQ ID NO:5, as determined by a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12, a gap extension penalty of 2, and a Blocks Substitution Matrix (BLOSUM) of 62, wherein the administering is effective to induce the temporal variation in the microbiota of the subject having the stroke.
Dependencies are inferred from the claim text.