Liposomal-gold nanoparticles for drug delivery into the brain
OwnerPablo Vivas-Mejia, Nilmary Grafalsinventors
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Abstract
The present invention discloses targeting microRNAs as a potential therapeutic target for cancer, more particularly glioblastoma (GBM). It discloses targeting microRNAs with gold-nanoliposomes labeled with brain targeting-peptides inducing a significant cell growth arrest and inhibition of miRNA-92b, an aberrantly abundant miRNA found in GBM cells. Furthermore, it delivers gold-nanoliposomes to the brain by crossing the blood brain barrier (BBB) and reaching cancer tumors.
Claims8
A nanoliposomal formulation for treating cancer comprising nanoparticles composed of SNAs encapsulated inside a peptide-conjugated liposome for the delivery of RNAi-based therapies.
A method for treating cancer comprising a nanoliposomal formulation, wherein said nanoliposomal formulation comprises nanoparticles composed of SNAs encapsulated inside a peptide-conjugated liposome for the delivery of RNAi-based therapies.
Dependencies are inferred from the claim text.