Compound and use thereof
AssigneeNovagenesis Therapeutix (Suzhou) Limited
InventorsFeng QIAN, Zhengsheng LIU
Life of this patent
Estimating the term…
Abstract
A compound represented by formula (I), or an isomer, a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, pharmaceutically acceptable salts or a prodrug thereof.
Claims20
A compound, comprising a tumor stroma-regulating group and a cytotoxic group that are coupled to each other, wherein the tumor stroma-regulating group is configured to regulate tumor stroma, and the cytotoxic group is configured to kill tumor cells.
A compound, comprising one of the following structures, or comprising one of isomers, stereoisomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs of the following structures:
- wherein R1 is independently calcipotriol, cyclopamine, Ganciclovir, Fingolimod, all-trans retinoic acid or hyaluronidase;
- and
- R2 is independently triptolide, paclitaxel, docetaxel, adriamycin, camptothecin, hydroxycamptothecin, 5-fluorouracil, Gemcitabine, Cisplatin, Irinotecan, Oxaliplatin, Pemetrexed, Capecitabine, Epirubicin, Sorafenib, Gefitinib, Erlotinib, Imatinib, Nilotinib, Dasatinib, Everolimus, Sunitinib, Ibrutinib, Crizotinib, Pazopanib, Carfilzomib, Tofacitinib, Axitinib, Regorafenib, Verofenib, Sirolimus, Ponatinib, Levatinib, Olaparib, Ceritinib, Romidepsin, Alectinib, Belinostat, Bosutinib, Vandetanib, Cabozantinib, Afatinib, Trametinib, Dabrafenib, or Lapatinib.
A compound, being a compound represented by formula (I), or being an isomer, a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound represented by formula (I),
Dependencies are inferred from the claim text.