K-ras modulators

A compound having the formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• Y is N or CH;
• Ring A is a C3-C7 cycloalkyl or 3 to 7 membered heterocycloalkyl;
• E is
• Y2 is N or CH;
• L1 is a bond;
• L2 is a bond, —C(O)—, —NR7B—, —NR7BC(O)—, —C(O)NR7B—, wherein R7B is hydrogen;
• L4 is a bond, —C(O)—, —NR4—, —NR4C(O)—, —C(O)NR4—, substituted or unsubstituted C1-C3 alkylene, or substituted or unsubstituted 2 to 3 membered heteroalkylene;
• R1 is independently halogen, —CX13, —CHX12, —CH2X1, —CN, —SO2Cl, —SOn1R10, —SOv1NR7R8, —NHNR7R8, —ONR7R8, —NHC═(O)NHNR7R8, —NHC(O)NR7R8, —N(O)m1, —NR7R8, —C(O)R9, —C(O)—OR9, —C(O)NR7R8, —OR10, —NR7SO2R10, —NR7C(O)R9, —NR7C(O)OR9, —NR7OR9, —OCX13, —OCHX12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and two adjacent R1 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is independently oxo, halogen, —CX23, —CHX22, —CH2X2, —CN, —SO2Cl, —SOn1R14, —SOv2NR11R12, —NHNR11R12, —ONR11R12, —NHC═(O)NHNR11R12, —NHC(O)NR11R12, —N(O)m2, —NR11R12, —C(O)R14, —C(O)—OR14, —C(O)NR11R12, —OR15, —NR11SO2R15, —NR11C(O)R14, —NR11C(O)OR14, —NR11OR14, —OCX23, —OCHX22, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and
• two adjacent R2 substituents or two R2 substituents bonded to the same atom may optionally be joined to form a substituted or unsubstituted cycloalkyl or substituted or unsubstituted heterocycloalkyl;
• R4 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;
• R16 is independently halogen, CX163, —CHX162, —CH2X16, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX163, —OCHX162, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7, R8, R9, R10, R11, R12, R14, and R15 are independently hydrogen, halogen, halogen, —CX3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX3, —OCHX2, —CHX2, —CH2X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 and R8 substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• each X1, X2, and X16 is independently —F, —Cl, —Br, or —I;
• n1, n2, v1, and v2 are independently an integer from 0 to 4;
• m1 and m2 are independently 1 or 2;
• z1 is independently an integer from 0 to 5;
• z2 is independently an integer from 0 to 10;
• and
• z16 is an integer from 0 to 4;