Oral composition with immunomodulating effect on natural killer cells

A method of treating recurrent spontaneous abortions or repeated implantation failures in a human female subject, comprising:

• providing a composition, comprising, as active ingredients:
• a combination of fatty acids or esters thereof,
• wherein the human female subject has 12% or more of peripheral blood NK cells in total peripheral blood cells, and/or
• the cytotoxicity of the peripheral blood NK cells of the human female subject is at least 10% higher than the mean cytotoxicity of a control population of healthy human females of reproductive age with no reproductive failures and who have given birth to at least one child, and
• administering the composition orally, to the human female subject, for 15 to 70 days, wherein the total amount of fatty acids or esters thereof administered per day is from 0.03 g/kg of body weight to 1 g/kg of body weight, calculated as fatty acids;
• thereby reducing immune-mediated sub-fertility for the human female subject.