Composition for cross talk between estrogen receptors and cannabinoid receptors

A composition for cross talk between estrogen receptors and cannabinoid receptors, comprising a conjugate of a chelator and a receptor ligand, and a metal ion,

• wherein the chelator comprises a nitrogen containing tetraazacyclic ring, and the nitrogen containing tetraazacyclic ring is a cyclam-carboxylic acid, or a cyclen-carboxylic acid;
• the receptor ligand comprises non-steroidal tamoxifen, wherein in the conjugate, the non-steroidal tamoxifen is joined with the chelator by a —CH2—CH2—CH2-O-CH2-CHOH— group, and in the —CH2—CH2—CH2—O—CH2—CHOH— group, the left terminal —CH2 is directly joined to an ethylene of a triphenylethylene group in the non-steroidal tamoxifen, and the right terminal —CHOH— is joined to the chelator side;
• and
• wherein the metal ion is 99mTc 67,68Ga, 60,61,62,64,67Cu, 111In, 166Ho, 186,188Re, 90Y, 177Lu, 223Ra, 225Ac, and 89Zr, 117mSn, 153SM, 89Sr, 59Fe, 212Bi, 211At, 45Ti, Tc, Sn, Cu, In, Tl, Ga, As, Re, Ho, Y, Sm, Se, Sr, Bi, Fe, Mn, Lu, Co, Pt, Ca, Rh, Eu, Tb, or a combination thereof.