Process for producing a pharmaceutical composition containing micro particles

A process for preparing a pharmaceutical composition, the process comprising:

• i) obtaining a mixture comprising ingredients (A), (B) and (C) having a molecular weight M measured by gel permeation chromatography;
• and
• ii) mixing the mixture with a pharmaceutically active ingredient (D), a hydrophobic ingredient (E) and an amphipathic ingredient (F) at a temperature ranging from about 30° C. to 70° C. for a period of T minutes, thereby producing the pharmaceutical composition comprising micro particles dispersed in a matrix,
• wherein:
• T satisfies:
• 0.00136M−230<T<0.00136M−169;
• the ingredient (A) is a polyhydric alcohol;
• the ingredient (B) is an inorganic salt of magnesium, calcium or barium, or a hydrate thereof;
• and
• the ingredient (C) is a water-soluble polymer.