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US 2021/0196628 A1Published application
Ophthalmic emulsion
AssigneeAlcon Inc.
InventorsHoward Allen Ketelson, David L. Meadows
Life of this patent
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Abstract
The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
Claims17
An ophthalmic emulsion, the emulsion comprising:
- water forming an aqueous phase;
- oil forming an oil phase;
- a hydrophilic surfactant having an HLB value of at least 8;
- a hydrophobic surfactant having an HLB value of below 8;
- a charged phospholipid;
- borate;
- a mucoadhesive galactomannan polymer;
- and
- wherein the emulsion is free of a benzalkonium chloride,
- wherein:
- i. the oil phase is in droplets within the aqueous phase and the droplets have an average diameter that is no greater than about 1000 nm, but is at least 10 nm, wherein the average diameter is corresponding to 90% of the cumulative undersize distribution by volume measured using a Microtrac S3500 Particle Size Analyzer (Software Version 10.3.1);
- and
- ii. the borate and galactomannan polymer cooperatively act to form a gel upon instillation of the emulsion in an eye of an individual.
10 more elements
Dependencies are inferred from the claim text.