Systems for enteric delivery of therapeutic agents

A system for enteric delivery of a therapeutic drug, comprising:

• one or more carrier members comprising a carrier polymer and a therapeutic agent,
• the system configurable in a compacted configuration and an expanded configuration, wherein the system is configured to (1) expand from the compacted configuration to the expanded configuration within the small intestine, or (2) expand from the compacted configuration to the expanded configuration within the stomach and pass through the pylorus without substantial release of the therapeutic agent until reaching the small intestine;
• wherein the system is sized to maintain contact with the intestinal wall of the small intestine by applying an outwardly directed pressure to the intestinal wall and transport at least a portion of the therapeutic agent across the enteric mucosa of the small intestine;
• and
• wherein at least a portion of the system loses structural integrity after a period of time within the small intestine to release the outwardly directed pressure.