Lyophilized formulation sealed in glass container
OwnerShogo YAMASHITA, Yuta YOSHIZAWAinventors
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Abstract
The present invention provides a lyophilized formulation containing a therapeutic agent and a surfactant sealed in a glass container, wherein an inner surface of the glass container is sulfur-treated or VIST-treated.
Claims15
A lyophilized formulation comprising a therapeutic agent and a surfactant sealed in a glass container, wherein an inner surface of the glass container is sulfur-treated or VIST-treated.
A method for producing a lyophilized formulation, comprising
- (a) providing a glass container having a sulfur-treated or VIST-treated inner surface;
- (b) introducing a pre-lyophilization solution comprising a therapeutic agent and a surfactant into the glass container;
- and
- (c) performing lyophilization.
A method for preventing or reducing fogging of a glass container for a lyophilized formulation, comprising
- (a) providing a glass container having a sulfur-treated or VIST-treated inner surface;
- (b) introducing a pre-lyophilization solution comprising a therapeutic agent and a surfactant into the glass container;
- and
- (c) performing lyophilization.
Use of a glass container having a sulfur-treated or VIST-treated inner surface in order to prevent or reduce fogging of glass upon lyophilization when a lyophilized formulation is produced.
Dependencies are inferred from the claim text.