Distorted gold (i)-phosphine complexes and and methods for use as antifungal agents
AssigneeUniversity of Kentucky Research Foundation
InventorsSylvie Garneau-Tsodikova, Emily K Dennis, Jong Hyun Kim, Samuel G. Awuah
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Abstract
The presently-disclosed subject matter describes distorted gold (I) phosphine compounds. The presently-disclosed subject matter also describes a method for killing fungus comprising contacting fungus with distorted gold (I) phosphine compounds. The presently-disclosed subject matter further describes a method of preventing or disrupting a biofilm on a surface comprising contacting a surface with distorted gold (I) phosphine compounds.
Claims20
A composition comprising a compound having the following formula (I) or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 and R2 are selected from substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, and R1 and R2 may optionally cyclize to form a 5 or 6 membered cycloalkyl;
- and
- the compound is in linear or square planar form.
Dependencies are inferred from the claim text.