Translation modeling methods and systems for simulating sensor measurements

A method of estimating a glucose level using a first glucose sensing arrangement, the method comprising:

• obtaining a translation model for output of the first glucose sensing arrangement, the translation model being based at least in part on relationships between first sensor measurement data obtained from instances of the first glucose sensing arrangement and second sensor measurement data obtained from instances of a second glucose sensing arrangement, the second glucose sensing arrangement having a type or configuration different from the first glucose sensing arrangement;
• obtaining historical sensor measurement data associated with the second glucose sensing arrangement;
• obtaining historical reference measurement data corresponding to the historical sensor measurement data;
• determining simulated sensor measurement data for the first glucose sensing arrangement by applying the translation model to the historical sensor measurement data;
• deriving a glucose estimation model for the first glucose sensing arrangement using the simulated sensor measurement data and the historical reference measurement data;
• and
• thereafter inputting measurement outputs from an instance of the first glucose sensing arrangement to the glucose estimation model to obtain an estimated sensor glucose measurement value.