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AssigneeInstituto de Patologia e Imunologia da Universidade do Porto (IPATIMUP)
InventorsCelso ALBUQUERQUE REIS, Stefan MEREITER, Ana Maria RODRIGUES LEITE DE MAGALHÄES, Karol POLOM, Franco ROVIELLO
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The present invention refers to the use of antibodies against the Thomsen-Friedenreich (TF) as reagents for in vitro diagnostics of Microsatellite Instability (MSI). Another aspect of this invention refers to a method for the in vitro diagnostics of MSI comprising the said composition employing the anti-TF antigen antibodies and measuring the expression of the TF antigen in a tissue sample. The present invention further refers to a kit comprising the above mentioned compositions for detecting MSI by conducting the present invention's method. The use, composition, methods and kit may be advantageously applied to significantly facilitate the identification of MSI in the clinical setting through a single marker-based sensitive and specific detection of MSI in patients with cancers of gastric, colorectal and other tissues for diagnostics, prognostics or prediction of response to treatment.
Use of an antibody with affinity for the Thomsen-Friedenreich (TF) antigen as a reagent for in vitro diagnostics of Microsatelite Instability (MSI).
A reagent composition for in vitro diagnostics of MSI characterized by comprising, an antibody with affinity for the TF antigen.
A composition for in vitro diagnostics of MSI characterized by comprising, a lectin with affinity for the TF antigen, for example Jacalin.
Dependencies are inferred from the claim text.