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US 2021/0172947 A1Published application
Method
AssigneeImperial College of Science, Technology and Medicine
InventorsMuhunthan THILLAI, Ajit LALVANI, Robert PARKER
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Abstract
The present invention relates to a method for the diagnosis of sarcoidosis. In particular, the present invention relates to a method for the differential diagnosis of sarcoidosis versus tuberculosis infection.
Claims8
A method of differentiating between sarcoidosis and tuberculosis infection in a subject, the method comprising:
- (a) measuring the level of a sarcoidosis-specific biomarker in a sample taken from the subject;
- (b) measuring the level of a tuberculosis-specific biomarker in the same sample;
- (c) calculating the ratio of the sarcoidosis-specific biomarker to the tuberculosis-specific biomarker;
- and (d) comparing the ratio of the sarcoidosis-specific biomarker to the tuberculosis-specific biomarker to one or more standard values, where a calculated ratio less than a standard value is indicative of sarcoidosis and a calculated ratio higher or equal to a standard value is indicative of tuberculosis infection.
1 more element
The method of claim 3, wherein the standard value is 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5 or 5.0.
A method of diagnosing sarcoidosis in a subject, the method comprising:
- (a) measuring the level of a sarcoidosis-specific biomarker in a sample taken from the subject;
- (b) measuring the level of a tuberculosis-specific biomarker in the same sample;
- (c) calculating the ratio of the sarcoidosis-specific biomarker to the tuberculosis-specific biomarker;
- and (d) comparing the ratio of the sarcoidosis-specific biomarker to the tuberculosis-specific biomarker to one or more standard values, where a calculated ratio less than a standard value is indicative of a positive sarcoidosis diagnosis.
1 more element
A method of diagnosing sarcoidosis in a subject, the method comprising:
- (a) measuring the level of CSFR1 in a sample taken from the subject;
- and (d) comparing the level of CSFR1 to one or more standard values, where a CSFR1 level above a standard value is indicative of a positive sarcoidosis diagnosis.
Dependencies are inferred from the claim text.