Apparatus for analyzing and detecting interactions and reactions of molecules
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorNongjian Tao
Life of this patent
Estimating the term…
Abstract
An apparatus for label-free analysis of molecules, including interactions and reactions of the molecules, is disclosed. The apparatus is based on detecting molecule movement under the influence of an external electric field. The apparatus is able to achieve sensitive detection of molecular binding to proteins or other molecules, and conformational changes of proteins or other molecules and biochemical reactions of the proteins or other molecules. Applications of the apparatus include screening of drug molecules, kinetic analysis of posttranslational modification of proteins, and small molecule-protein interactions.
Claims20
An apparatus for analyzing and detecting interactions and reactions of molecules, comprising:
- a surface configured to conduct electricity;
- a molecular bridge configured to bind to said surface and to bind to a molecule;
- at least one electrode configured to form an electric field between the at least one electrode and the surface;
- and
- a solution, wherein the surface, the molecular bridge, and at least a portion of the electrode are submerged in the solution.
Dependencies are inferred from the claim text.