Genetic variant panels and methods of generation and use thereof

-47. (canceled)

A method for modifying one or more outcomes of one or more first nucleic acid edits in a first genomic region of interest, the method comprising:

• (a) obtaining one or more partitions of clonal cells, wherein each partition of clonal cells comprises a first nucleic acid edit from the one or more first nucleic acid edits in a first genomic region of interest, and wherein each clonal cell in a partition is clonally expanded from a single cell obtained from contacting one or more original cells with one or more first nucleic acid editing units;
• and
• (b) contacting each partition of clonal cells with one or more second nucleic acid editing units, wherein each second nucleic acid editing unit is designed to introduce a second nucleic acid edit in a second genomic region of interest thereby producing one or more partitions of twice edited cells, and wherein an outcome of the second nucleic acid edit modifies the outcome of the first nucleic acid edit.

-110. (canceled)

-205. (canceled)

A variant panel comprising:

• one or more partitions of clonal cells, wherein each clonal cell in a partition is clonally expanded from a single cell obtained from contacting one or more original cells with the one or more nucleic acid editing units, and wherein the clonal cells comprise at least one nucleic acid edit in one or more genomic regions of interest.

-258. (canceled)