Method and device for the detection of molecular interactions

A device for qualitatively and/or quantitatively detecting molecular interactions between probe molecules and target molecules in a sample solution, said device comprising:

• a micro-array having a substrate, on which probe molecules are immobilized on array elements, said micro-array being arranged on a first surface of the device;
• and
• a reaction chamber formed between the first surface having said micro-array arranged thereon, and a second surface, wherein the distance between said micro-array and said second surface is variable such that the sample solution between said micro-array and said second surface can be essentially removed without removing the sample solution from the reaction chamber.