Streamlined methods for making liquid media

A method of making a liquid medium comprising:

• i) grouping media components into groups based on their pH, solubility and concentration,
• ii) converting an amino acid's free base form/salt form to target a particular pH according to the components in the formulation;
• iii) performing addition of the groups in an order that permits optimal solubilization of said group;
• wherein the resulting liquid medium requires lesser acid and/or base addition to solubilize the groups compared to a medium that is not prepared using steps i) ii) and iii) above.