Fully human antibodies against ox40, method for preparing the same, and use thereof

An isolated antibody or the antigen-binding portion thereof, wherein the isolated antibody or the antigen-binding portion thereof comprises:

• A) one or more heavy chain CDRs (CDRHs) selected from at least one of the group consisting of:
• (i) a CDRH1 with at least 90% sequence identity to a CDRH1 as set forth in one of the sequences selected from the group consisting of SEQ ID NOs:
• 1, 7, 13, 15, 21 and 27;
• (ii) a CDRH2 with at least 90% sequence identity to a CDRH2 as set forth in one of the sequences selected from the group consisting of SEQ ID NOs:
• 3, 9, 17, 23 and 29;
• and
• (iii) a CDRH3 with at least 90%, sequence identity to a CDRH3 as set forth in one of the sequences selected from the group consisting of SEQ ID NOs:
• 5, 11, 19, 25 and 31;
• B) one or more light chain CDRs (CDRLs) selected from at least one of the group consisting of:
• (i) a CDRL1 with at least 90% sequence identity to a CDRL1 as set forth in one of the sequences selected from the group consisting of SEQ ID NOs:
• 2, 8, 14, 16, 22 and 28;
• (ii) a CDRL2 with at least 90% sequence identity to a CDRL2 as set forth in one of the sequences selected from the group consisting of SEQ ID NOs:
• 4, 10, 18, 24 and 30;
• and
• (iii) a CDRL3 with at least 90% sequence identity to a CDRL3 as set forth in one of the sequences selected from the group consisting of SEQ ID NOs:
• 6, 12, 20, 26 and 32;
• or
• C) one or more CDRHs of A) and one or more CDRLs of B).