Human monoclonal antibodies against epha4 and their use

A method for treating neurodegeneration or an affective disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an isolated monoclonal antibody or an antigen binding fragment thereof, comprising:

• a) a heavy chain variable domain comprising the amino acid sequence set forth as SEQ ID NO:3 and a light chain variable domain comprising the amino acid sequence set forth as SEQ ID NO:6;
• or
• b) a heavy chain variable domain comprising the amino acid sequence set forth as SEQ ID NO:4 and a light chain variable domain comprising the amino acid sequence set forth as SEQ ID NO:7, wherein the monoclonal antibody or antigen binding fragment thereof specifically binds the EphA4 ligand binding domain.