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AssigneeThe Johns Hopkins University
InventorAnirudha SINGH
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A collagen-based or gelatin-based formulation that is compliant yet strong and has a high suture-strength value is disclosed. This material is simple to synthesize, behaves like a rubbery material, and is the first type of solely collagen-based compliant material without using elastin. The formulation maintains the strength of collagen, but can be stretched to several times its initial dimension and can be sutured without leaking. The suture retention strength can reach up to 350-grams force. The presently disclosed collagen-based formulation can be used in variety of applications where high strength, compliance, or stretchability is required, such as in urinary tissues, intestinal tissues, heart tissues, and skin.
A composition comprising a modified collagen or gelatin, wherein an amine of at least one or more lysine or hydroxylysine residues of the collagen or gelatin is covalently bond to a C2 to C18 substituted or unsubstituted, saturated or unsaturated aliphatic hydrocarbon chain.
The composition of claim 7, wherein p is 1 and n is selected from the group consisting of 9, 10, 11, and 12.
A method for preparing a modified collagen or gelatin, the method comprising contacting a collagen or gelatin sample with a solution comprising a C2-C18 succinic anhydride or C2-C18 N-hydroxysuccinimide ester and a suitable reagent for a period of time to form a modified collagen or gelatin.
Dependencies are inferred from the claim text.