Combinatorial antibiotic derivatives based on supramolecular structures

New combinatorial derivatives of antibiotics based on supramolecular structures and a method for their preparation, wherein the supramolecular structures (B) are obtained by combinatorial synthesis of a polyfunctional antibiotic (A1) from one source molecule with two or more groups available for covalent modification in the reaction, as at least with two different covalent modifiers (M2 and M3) simultaneously according to the synthesis scheme

• mA1+kM2+kM3=mB
• In this case, a combinatorial mixture of modified derivatives of the original molecule is formed, with a maximum variety of derivatives, and as biologically active substances for creating pharmaceutical compositions, a whole combinatorial mixture is used in the form of a supramolecular structure without separation into individual components.
• k=n×(2n−1) (1)
• m=4×(3×2n-2−1) (2)
• e