Chemical compounds

A compound of Formula I:

• wherein:
• A is C(R5) or N;
• R5 is H, C1-3 alkyl, CN or halogen;
• R2 is 3-7 membered heterocycloalkyl or 3-7 membered cycloalkyl;
• optionally substituted with one to three substituents independently selected from the group consisting of R10, OR10, SR10, S(O)R10, S(O)2R10, C(O)R10, C(O)OR10, OC(O)R10 OC(O)OR10), NH2, NHR10, N(R10)2, NHC(O)H, NHC(O)R10, NR10C(O)H, NR10C(O)R10, NHS(O)2R10, NR10S(O)2R10, NHC(O)OR10, NR10C(O)OR10, NHC(O)NH2, NHC(O)NHR10, NHC(O)N(R10)2, NR10C(O)NH2, NR10C(O)NHR10, NR10C(O)N(R10)2, C(O)NH2, C(O)NHR10, C(O)N(R10)2, C(O)NHOH, C(O)NHOR10, C(O)NHS(O)2R10, C(O)NR10S(O)2R10, S(O)2NH2, S(O)2NHR10, S(O)2N(R10)2, S(O)2NHC(O)OR10, S(O)2NR10C(O)OR10, C(O)H, C(O)OH, OH, CN, NO2, F, Cl, Br and I;
• wherein one or more ring CH2 groups can optionally be replaced by a corresponding number of —C(O) groups, and one or more ring sulfur or nitrogen atoms may be optionally oxidized to form S-oxides or N-oxides;
• R10, at each occurrence, is independently selected from the group consisting of a 3 to 6 membered cycloalkyl or heterocycloalkyl group, C1-6 alkyl, —O—C1-6 alkyl, C1-6 alkyl-O—C1-6 alkyl, NH2, C(O)NH2, C(O)H, C(O)OH, OH, CN, NO2, F, Cl, Br and I;
• wherein two R10 groups together with the atoms to which they are attached may form a 3 to 6 membered cycloalkyl or heterocycloalkyl group;
• and each aforementioned R10 alkyl, cycloalkyl and heterocycloalkyl group may be further substituted with one or two substituents independently selected from CN, OH, halogen, C1-3 alkyl, —O—C1-3 alkyl, NH2, NH—C1-3 alkyl, and NHC(O)—C1-3 alkyl;
• R4 is
• wherein X and Y together with the atoms to which they are attached, form a 5 to 7 membered heterocycloalkyl ring which, in addition to the bridge nitrogen, may contain one or two heteroatoms selected from N, O, and S, which ring may be saturated or partially saturated;
• wherein one or two ring CH2 groups can optionally be replaced by a corresponding number of —C(O) groups, one or more ring sulfur or nitrogen atoms may be optionally oxidized to form S-oxides or N-oxides and wherein the ring may be substituted on a ring carbon by one or two R10 substituents or on a ring nitrogen by an R12 substituent;
• J is N or CR11;
• and
• R11 is H, or C1-3 alkyl;
• R12 is at each occurrence independently selected from the group consisting of a 3 to 6 membered cycloalkyl or heterocycloalkyl group, C1-6 alkyl, C1-6 alkyl-O—C1-6 alkyl, C(O)NH2, or C(O)H;
• wherein R12 alkyl, cycloalkyl and heterocycloalkyl group may be further substituted with one or two substituents independently selected from CN, OH, and halogen, C1-3 alkyl, NH2, and NH—C1-3 alkyl, NHC(O)—C1-3 alkyl or pharmaceutical acceptable salts thereof.