Prostaglandin analogs and uses thereof

A prostaglandin analog represented by the following Chemical Formula I, or a pharmaceutically acceptable salt, stereoisomer, solvate, polymorph, ester, tautomer, or prodrug thereof.

• wherein,
• X is non-substituted or substituted —(C1-C8)alkyl, —[(C1-C8)alkoxy](C1-C8)alkyl-, —(C1-C8)alkylcarboxylic acid —(C1-C8)alkylcarboxylester, —(C1-C8)akenyl, [(C1-C8)alkoxy](C1-C8)alkenyl, —(C1-C8)alkenyl acid, —(C1-C8)alkenyl ester, —(C1-C8)alkylamide, or —(C1-C8)alkenylamide;
• Y is (C1-C8) alkyl or (C1-C8) alkenyl, which is optionally substituted with one or more substituent(s) selected from the group consisting of hydroxy, oxo, halo, (C1-C6)alkyl, (C1-C6)alkoxy, (C6-C10) aryl, (C6-C10) aryloxy being optionally substituted with (C1-C3) alkyl or halo(C1-C3) alkyl, (C3-C10) cycloalkyl;
• A1 and A2 are each independently, CH, CH2, NH or N;
• Z is ═O, ═CH2, , or ;
• Z″ is ═O, ═CH2, , or , Rd is H, (C1-C3) alkyl, (C1-C6)acylcarbonyl or tetrahydropyranyl,
• in the Chemical Formula, the notation is a single bond or a double bond.