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AssigneeKing Abdullah University of Science and Technology
InventorsHicham Mansour, Roberto Incitti, Vladimir Bajic
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Described are epigenetic biomarkers of breast cancer and their use in breast cancer screening and diagnosing, or to provide disease prognosis in a subject. The epigenetic biomarkers include methylatable regions (MRs), which may be at least one segment from nucleic acid sequences represented in Table 1. Described are also methods of detecting the methylation level of MRs in the subject, the methylation score (mSCORE) of the subject, and using these values to evaluate a breast cancer risk in a subject, or diagnose a subject with breast cancer. Also described are methods of determining a risk of recurrence and disease prognosis in a subject undergoing or having undergone a treatment for breast cancer.
A method for determining the presence, absence, or risk of breast cancer in a subject comprising (i) detecting a methylation level in methylatable regions (MRs) of genomic DNA comprising SEQ IDs NOs:
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A method of detecting a DNA methylation level of an epigenetic biomarker in a subject, the method comprising:
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A substrate comprising one or more nucleic acid sequences attached thereto,
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Dependencies are inferred from the claim text.