Biomimetic lamellar tissue scaffolds

A method for treating a patient using a biomimetic scaffold comprising the steps of:

• providing a scaffold formed of one or more lamellae with a nanofiber array formed on a first surface of said one or more lamellae, said scaffold further comprising one or more interlamellar spaces wherein said nanofiber array protrudes into said interlamellar spaces;
• preparing a treatment site on said patient to receive said scaffold;
• and
• implanting said scaffold at said site.

A method for creating a tissue structure for implantation in a patient comprising the steps of:

• providing a scaffold formed of one or more lamellae with a nanofiber array formed on a first surface of said one or more lamellae, said scaffold further comprising one or more interlamellar spaces wherein said nanofiber array protrudes into said interlamellar spaces, and said scaffold is configured to mimic a native tissue structure;
• submerging said scaffold in a biologic solution comprising stem cells;
• maintaining said scaffold and biologic solution in a suitable bioreactor until said scaffold is replaced by extracellular matrix and said tissue structure is complete;
• and
• removing said tissue structure from said bioreactor;
• wherein said nanofiber array is configured for optimal stem cell propagation and differentiation into a predetermined cell type.