Methods and agents for treating infections
AssigneeThe Regents of the University of California
InventorsManish J. BUTTE, Maria I. GARCIA-LLORET
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Abstract
Methods are described for treating systemic fungal and mycobacterial infections by treatment to enhances a Th1 response, reduces a Th2 response, or the combination thereof. Agents that antagonize the IL-4, the IL-13 receptor, or the combination thereof achieve the desired results.
Claims19
A method for treating a fungal, mycobacterial or viral infection in a subject in need thereof, comprising administering to the subject an agent that enhances a Th1 response, reduces a Th2 response, or the combination thereof.
A method for determining whether subject is a candidate for therapy with an agent that enhances a Th1 response, reduces a Th2 response, or the combination thereof, comprising the steps of
- a. determining the presence of a defect in signaling related to interferon-gamma, STAT1, STAT3 or STAT4;
- or determining the presence of a genetic defect in IL12RB1, IL12RB2 or TYK2 genes or any PID gene, and
- b. if a defect in signaling is determined, initiating therapy.
A method for determining whether therapy with an agent that enhances a Th1 response, reduces a Th2 response, or the combination thereof, is effective in a subject with disseminated coccidiomycosis, comprising determining the ratio of cocci-specific Th1 to Th2 cells, wherein an increased ratio indicates effectiveness.
Dependencies are inferred from the claim text.