Heterobicyclic Carboxylic Acids and Salts Thereof

A pharmaceutically acceptable salt of a compound of Formula 1,

• wherein:
• R1 and R2 are independently selected from the group consisting of hydrogen, halo, C1-6 alkyl, C1-6 cycloalkyl, C1-6 fluorocycloalkyl, and C1-6 fluoroalkyl;
• or, R1 and R2, together with the carbon atom to which they are both attached, form a three- to six-membered carbocyclic group which is optionally substituted with Rc, or form a three- to six-membered heterocyclic group which contains one or two heteroatom(s) each independently selected from the group consisting of S, O, and NRb;
• each Rb is independently selected from the group consisting of hydrogen, halo, C1-6 alkyl, C1-6 cycloalkyl, C1-6 fluorocycloalkyl, C1-6 fluoroalkyl, aryl, heteroaryl, —C(O)—C1-6 alkyl, —C(O)-aryl, —S(O)2-alkyl, and —S(O)2-aryl;
• Y is O or S;
• X is a bond, ═CH—, CH2, O, or S;
• Ar1 and Ar2 are each independently selected from the group consisting of C3-6 cycloalkyl, aryl, heteroaryl and heterocyclyl, or a fused analog of C3-6 cycloalkyl, aryl, heteroaryl, and heterocyclyl, and Ar1 and Ar2 are each optionally substituted with one to three Rc groups;
• each Rc is independently selected from the group consisting of halo, C1-6 alkyl, C1-6 cycloalkyl, C1-6 fluorocycloalkyl, and C1-6 fluoroalkyl;
• Ra is —CO2H, —CO2M, —C(O)NHS(O)2Raa, or
• Raa is C1-6 alkyl, C1-6 haloalkyl, C1-6 cycloalkyl, C1-6 cyclohaloalkyl, aryl, or heteroaryl;
• M is a pharmaceutically acceptable salt or an ester prodrug group;
• is a 6,6- 5,5- 5,6- or 6,5-bicyclic group.