Compounds

A compound of formula I,

• wherein
• L is absent or —(C≡C)—,
• A is
• B is aryl or heteroaryl,
• C is heteroaryl,
• Y is N, C(OH) or CH,
• R1 is each independently selected from the group consisting of
• i) amino,
• ii) C1-6-alkyl,
• iii) C1-6-alkoxy,
• iv) cyano,
• v) halogen,
• vi) halogen-C1-6-alkyl,
• vii) halogen-C1-6-alkoxy, and
• viii) hydroxy;
• R2 is each independently selected from the group consisting of
• i) —(CH2)k—N(R4,R5),
• ii) —(C═O)—N(R4,R5),
• iii) halogen,
• iv) halogen-C1-6-alkyl,
• v) —NH—(C═O)—C1-6-alkyl, and
• vi) C1-6-alkyl, optionally substituted by OH;
• R3 is each independently selected from the group consisting of
• i) amino,
• ii) C1-6-alkyl,
• iii) C1-6-alkoxy,
• iv) cyano,
• v) halogen,
• vi) halogen-C1-6-alkyl,
• vii) halogen-C1-6-alkoxy, and
• viii) hydroxy;
• R4 is each independently selected from the group consisting of
• i) H, and
• ii) C1-6-alkyl;
• R5 is each independently selected from the group consisting of
• i) H,
• ii) C1-6-alkyl, and
• iii) —(C═O)—C1-6-alkyl;
• or R4 and R5 form together with the N they are attached to a heterocyclyl, which heterocyclyl is optionally be substituted by one to three R6.
• R6 is each independently selected from the group consisting of
• i) —OH,
• ii) halogen,
• iii) C3-8-cycloalkyl,
• iv) halogen-C1-6-alkyl,
• v) C1-6-alkoxy-C1-6-alkyl,
• vi) cyano-C1-6-alkyl,
• vii) C1-6-alkyl, and
• viii) —(C═O)—C1-6-alkyl;
• R7 is each independently selected from the group consisting of
• i) H,
• ii) halogen,
• iii) halogen-C1-6-alkoxy,
• iv) C1-6-alkoxy, and
• v) C1-6-alkyl;
• R8 is each independently selected from the group consisting of
• i) H,
• ii) halogen,
• iii) C1-6-alkoxy, and
• iv) C1-6-alkyl;
• R9 is each independently selected from the group consisting of
• i) H,
• ii) halogen,
• iii) halogen-C1-6-alkoxy,
• iv) C1-6-alkoxy, and
• v) C1-6-alkyl;
• k is 0, 1 or 2,
• n is 0, 1, 2, 3 or 4;
• m is 0, 1 or 2;
• p is 0 or 1;
• or a pharmaceutically acceptable salt thereof.