Crystal and salt of 4-(naphthalen-1-yl)-4h-1,2,4-triazole compound and preparation method therefor
AssigneeMedshine Discovery Inc.
InventorsJianfei WANG, Yang ZHANG, Jian LI, Shuhui CHEN
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Abstract
Disclosed are a crystal of a 4-(naphthalene-1-yl)-4H-1,2,4-triazole compound (1) and a preparation method therefor, also comprised are applications of the crystal in preparing a medicament for treating an abnormal uric acid level-related disease.
Claims23
A crystal form A, crystal form D or amorphous form I of compound 1, wherein the crystal form A of compound 1 has an X-ray powder diffraction pattern comprising characteristic diffraction peaks at angle 2θ of 7.16±0.2°, 17.98±0.2°, and 22.30±0.2″;
- the crystal form D of compound 1 has an X-ray powder diffraction pattern comprising characteristic diffraction peaks at angle 2θ of 9.19±0.2°, 14.41±0.2°, and 19.95±0.2°;
- the amorphous form I of compound 1 has an X-ray powder diffraction pattern as shown in FIG. 4;
7-17. (canceled)
A crystal form B or amorphous form II of compound 1a, wherein the crystal form B of compound 1a has an X-ray powder diffraction pattern comprising characteristic diffraction peaks at angle 2θ of 17.34±0.2°, 20.36±0.2°, and 27.12±0.2°;
- the amorphous form II of compound 1a has an X-ray powder diffraction pattern as shown in FIG. 10;
23-25. (canceled)
A crystal form C or amorphous form III of compound 1b, wherein the crystal form C of compound 1b has an X-ray powder diffraction pattern comprising characteristic diffraction peaks at angle 2θ of 17.24±0.2°, 18.68±0.2°, and 20.26±0.2°;
- the amorphous form III of compound 1b has an X-ray powder diffraction pattern as shown in FIG. 16;
31-33. (canceled)
Dependencies are inferred from the claim text.