Cyclopentane compounds
AssigneeDizal (Jiangsu) Pharmaceutical Co., Ltd.
InventorsXiaolin ZHANG, Weitao PAN, Grigorios NIKITIDIS, Jenny Susanna Marika LINDHAGEN
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Abstract
The present invention relates to cyclopentane compounds of Formula (1), physical forms thereof, processes for their production and their use in medicine.
Claims21
A compound of Formula I
- wherein:
- X is a) O, and R1 is a 6-membered aromatic or heteroaromatic ring selected from phenyl, pyridyl, pyrimidyl, pyrazinyl or pyridazyl, wherein R1 is optionally substituted with one or two substituents Y independently selected from F, Cl, Br, CN, OH, OC1-3alkyl, OCF3, C1-3alkyl, C(O)NH2, CF3 or cyclopropyl;
- or b) NR2, and wherein N, R1 and R2 together form a 5-membered aromatic heterocycle that is optionally substituted with one or two substituents Y that are independently selected from F, Cl, CN, or Me;
- R3 is independently selected from F, Cl, CN, methyl, methoxy, hydroxy and ethynyl;
- R4 is independently selected from F or Cl attached to C2, C4 or C5 of the piperidine ring;
- and
- the integers a and b are independently selected from 0, 1 or 2;
- or a pharmaceutically acceptable salt thereof.
(3R,5R)-5-fluoro-1-((1R,2R,4S)-4-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclopentyl)piperidin-3-amine, or a pharmaceutically acceptable salt thereof.
A crystalline form of (3R,5R)-5-fluoro-1-((1R,2R,4S)-4-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclopentyl)piperidin-3-amine.
Physical Form A of (3R,5R)-5-fluoro-1-((1R,2R,4S)-4-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclopentyl)piperidin-3-amine.
16-17. (canceled)
Dependencies are inferred from the claim text.