Anionic exchange-hydrophobic mixed mode chromatography resins

A chromatography matrix covalently linked to a ligand having the following formula:

• Chromatography matrix-(X)—N(R1)—(R2-L)n-Ar
• or an anionic salt thereof,
• wherein:
• X is a spacer;
• R1 is hydrogen or C1 to C6 alkyl optionally substituted with an —OH;
• R2 is C2 to C6 alkyl or C4 to C6 cycloalkyl;
• L is NR4, O, or S;
• n=1 or 2;
• and
• Ar is a 6-10 membered ring and:
• if Ar is aryl, the aryl is optionally substituted with up to five C1 to C3 unsubstituted alkyl, C3 to C6 branched alkyl, unsubstituted aryl, or fluorine groups;
• or
• if Ar is heteroaryl, the heteroaryl is optionally substituted with up to four unsubstituted alkyl groups,
• with the proviso that when R1 is hydrogen, R2 is C2 alkyl, L is NR4 or O, and n is 1, Ar is not phenyl.